Forced, not voluntary, exercise effectively induces neuroprotection in stroke
نویسندگان
چکیده
منابع مشابه
Forced, not voluntary, exercise improves motor function in Parkinson's disease patients.
BACKGROUND Animal studies indicate forced exercise (FE) improves overall motor function in Parkinsonian rodents. Global improvements in motor function following voluntary exercise (VE) are not widely reported in human Parkinson's disease (PD) patients. OBJECTIVE The aim of this study was to compare the effects of VE and FE on PD symptoms, motor function, and bimanual dexterity. METHODS Ten ...
متن کاملForced and voluntary exercise differentially affect brain and behavior.
The potential of physical exercise to decrease body weight, alleviate depression, combat aging and enhance cognition has been well-supported by research studies. However, exercise regimens vary widely across experiments, raising the question of whether there is an optimal form, intensity and duration of exertion that would produce maximal benefits. In particular, a comparison of forced and volu...
متن کاملForced exercise does not improve recovery after hemorrhagic stroke in rats.
Exercise can improve recovery following ischemia and intracerebral hemorrhage (ICH) in rodents. We tested whether forced exercise (EX; running wheel) prior to and/or following ICH in rats would reduce lesion volume and improve functional outcome (walking, skilled reaching, spontaneous paw usage) at 7 weeks post-ICH. A striatal hemorrhage was produced by infusing collagenase. First, we compared ...
متن کاملVoluntary Exercise Induces Astrocytic Structural Plasticity in the Globus Pallidus
Changes in astrocyte morphology are primarily attributed to the fine processes where intimate connections with neurons form the tripartite synapse and participate in neurotransmission. Recent evidence has shown that neurotransmission induces dynamic synaptic remodeling, suggesting that astrocytic fine processes may adapt their morphologies to the activity in their environment. To illustrate suc...
متن کاملVoluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity.
We have investigated potential mechanisms by which exercise can promote changes in neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (BDNF), its signal transduction receptor (trkB), and downstream effectors for the acti...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2008
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-008-0340-z